Targeting gene therapy vectors to CNS malignancies
نویسندگان
چکیده
منابع مشابه
Targeting gene therapy vectors to CNS malignancies.
Gene therapy offers significant advantages to the field of oncology with the addition of specifically and uniquely engineered mechanisms of halting malignant proliferation through cytotoxicity or reproductive arrest. To confer a true benefit to the therapeutic ratio (the relative toxicity to tumor compared to normal tissue) a vector or the transgene it carries must selectively affect or access ...
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Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in CFTR genes that affect chloride ion channel. The CF is a good nominee for gene therapy as the asymptomatic carriers are phenotypically normal, and the desired cells are accessible for vector delivery. Gene therapy shows promising effects involving the correction of gene or replacement of the mutant gene with the func...
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Introduction overview of the gene therapy field The gene therapy field has met with serious problems in the clinic that have overshadowed its tremendous potential. The death of an individual enrolled in a gene therapy trial at the University of Pennsylvania and the occurrence of leukemia in three children enrolled in the X-SCID (X-linked severe combined immunodeficiency disease) gene therapy tr...
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ژورنال
عنوان ژورنال: Journal of Neurovirology
سال: 1998
ISSN: 1355-0284,1538-2443
DOI: 10.3109/13550289809114514